ActiveDriverWGS: A Driver Discovery Tool for Cancer Whole Genomes

A method for finding an enrichment of cancer simple somatic mutations (SNVs and Indels) in functional elements across the human genome. 'ActiveDriverWGS' detects coding and noncoding driver elements using whole genome sequencing data. The method is part of the following publication: Candidate Cancer Driver Mutations in Distal Regulatory Elements and Long-Range Chromatin Interaction Networks. Molecular Cell (2020) <doi:10.1016/j.molcel.2019.12.027>.

Version: 1.1.1
Depends: R (≥ 3.5)
Imports: BSgenome, BSgenome.Hsapiens.UCSC.hg19, Biostrings, GenomeInfoDb, GenomicRanges, IRanges, S4Vectors
Suggests: knitr, testthat, BSgenome.Hsapiens.UCSC.hg38, BSgenome.Mmusculus.UCSC.mm9, BSgenome.Mmusculus.UCSC.mm10, rmarkdown
Published: 2020-09-17
Author: Juri Reimand [aut, cre], Helen Zhu [aut]
Maintainer: Juri Reimand <juri.reimand at utoronto.ca>
License: GPL-3
NeedsCompilation: no
Materials: README NEWS
CRAN checks: ActiveDriverWGS results

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Reference manual: ActiveDriverWGS.pdf
Vignettes: ActiveDriverWGS
Package source: ActiveDriverWGS_1.1.1.tar.gz
Windows binaries: r-devel: ActiveDriverWGS_1.1.1.zip, r-release: ActiveDriverWGS_1.1.1.zip, r-oldrel: ActiveDriverWGS_1.1.1.zip
macOS binaries: r-release: ActiveDriverWGS_1.1.1.tgz, r-oldrel: not available
Old sources: ActiveDriverWGS archive

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